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KMID : 1007520190280051543
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Food Science and Biotechnology
2019 Volume.28 No. 5 p.1543 ~ p.1551
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Dansameum regulates hepatic lipogenesis and inflammation in vitro and in vivo
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Ahn Sang-Hyun
Lee Kang-Pa
Kim Ki-Bong
Choi Jun-Yong
Park Sun-Young
Cheon Jin-Hong
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Abstract
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Although the clinical guidelines for nonalcoholic fatty liver disease (NAFLD) therapy recommended hepato-protection and exercise to reduce body weight, no established medication exists for NAFLD treatment. Thus, the effect of a candidate substance, dansameum (DSE), using an in vitro and NAFLD mouse model (that is, apolipoprotein E-Knockout mice), were investigated. The molecular pathways for lipogenesis and inflammation were evaluated using Nile staining, Western blotting, reverse transcription-polymerase chain reaction, and immunohistochemistry. It was shown that DSE significantly ameliorated the production of lipogenesis-related factors, including liver X receptor-α, peroxisome proliferator-activated receptor-γ, sterol regulatory element binding protein-1, fatty acid synthase, acetyl-CoA carboxylase 1, and CD36. In addition, DSE significantly reduced the production of inflammation factors, including interleukin-1β, interleukin-6, and nuclear factor kappa B. Furthermore, DSE significantly reduced the phosphorylation of c-Jun amino terminal kinase. Taken together, this suggests that DSE may be a functional food candidate for regulating NAFLD, based on its effects.
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KEYWORD
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Nonalcoholic fatty liver disease, Lipogenesis, Inflammation, Steatosis, Traditional Chinese medicine, Functional foods
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